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Natural Thymocytotoxic Autoantibodies in Autoimmune and Normal Mice¹

From the Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Natural thymocytotoxic autoantibodies (NTA) were found in all mouse strains. Among those strains that show autoimmune syndromes resembling human systemic lupus erythematosus (SLE), the NZB and NZBxNZW had high levels of NTA, the BXSB had moderate levels, and the MRL/1 and MRL/n had very low levels. In addition, some normal strains had high levels, sometimes even higher than the autoimmune strains. The NTA were mostly IgM and were present, but not concentrated, in the cryoprecipitates of the autoimmune mouse strains. In most strains, they were directed toward an antigen shared by thymocytes and brain. The failure to find high levels of NTA in all autoimmune mouse strains, as well as the finding of very high levels in some normal strains, make it unlikely that such autoantibodies are a fundamental etiologic factor in all murine SLE.

Footnotes

¹ This is publication No. 1627 from the Immunology Departments, Scripps Clinic and Research Foundation, La Jolla, California. This work was supported by United States Public Health Service Grants AI-07007, N01 CP-71018, CA-16600, and the Elsa U. Pardee Foundation.

² R.A.E. is supported by Helen Hay Whitney Foundation Postdoctoral Fellowship #324. Present Address: Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27514.

³ A.N.T. is the recipient of an RCDA application CA-00303.

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