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In Situ Lymphoid Cells of Mouse Mammary Tumors

IV. Comparison of Functional Activity of Lymphoid Cells Separated from Mammary Tumors to That of Spleen and Lymph Node Cells of Tumor-Sensitized Mice¹

From the Department of Cell Biology, Baylor College of Medicine, Houston, Texas 70030 and the Department of Medicine, Roger Williams General Hospital, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912

Abstract

Lymphoid cells isolated from several types of mouse mammary tumors are capable of stimulating tumor cell growth or survival in MCT assays. Lymph node and spleen cells of mice bearing such a tumor are specifically cytotoxic to the tumor cells. Surgical removal of the tumor is followed in 4 to 7 days by the appearance of stimulatory capacity in spleens and lymph nodes. By day 10, cytotoxic cells specific for the sensitizing tumor are again detected. These reach a peak on day 13. By day 17 no reactivity is detectable. The functional distribution of tumor-reactive lymphoid cells is different between tumor masses and peripheral lymphoid organs.

Footnotes

¹ This work was supported by Grant CA 17074 from the National Institutes of Health, Bethesda, Maryland.

² Present address: Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.

³ Please address reprint requests to: Dr. G. H. Heppner, Department of Immunology, Michigan Cancer Foundation, 110 E. Warren Avenue, Detroit, Michigan 48201 (present address).