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The Proliferative Response of Human Lymphocytes to Antigen Is Suppressed Preferentially by Lymphocytes Precultured with the same Antigen¹

From the Department of Medicine, Infectious Disease and Immunology Division, New York University School of Medicine, New York, New York 10016

Abstract

Human blood lymphocytes activated in vitro with antigen to which the donor is reactive are capable of suppressing the secondary proliferative response of autochthonous fresh cells to antigen. Both antigen-specific and antigen-nonspecific suppression can be detected in each experiment. These suppressor cells act by decreasing the number of lymphocytes entering the proliferative response rather than by slowing or otherwise inhibiting ongoing proliferation. The suppressor cells must be added soon after fresh cells are stimulated with antigen to be effective, but the suppressor cells themselves need not proliferate to exert their effect. Suppressor cells are optimally effective when added in numbers equal to those of the responding population, but still exert a significant effect at one-eighth that number.

Footnotes

¹ This work was supported by Grant CA-19529 awarded by the National Cancer Institute, Department of Health, Education and Welfare, and by United States Public Health Service Training Grant AI-00005.

² United States Public Health Service Trainee.

³ Address reprint requests to Fred T. Valentine, M.D., Department of Medicine, New York University Medical Center, 550 First Avenue, New York, New York 10016.