HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Imamura, M. Articles by Martin, W. J. Search for Related Content PubMed Articles by Imamura, M. Articles by Martin, W. J.

Lung Tumor-Reactive Cytotoxic Lymphocytes Generated in Mixed Lymphocyte Reaction Between C3HfeB/HeN (H-2^kb) and C3H/HeN (H-2^k) Strain Mice

From the Department of Health, Education and Welfare, Food and Drug Administration, Bureau of Biologics, Division of Virology, 8800 Rockville Pike, 8800 Rockville Pike, Bethesda, Maryland 20014

Abstract

The tumor-associated transplantation antigen expressed by several transplacentally induced lung tumors of C3HfeB/HeN mice (H-2^kb haplotype) has previously been shown to exist as a normal tissue alloantigen in mice of known H-2^k and H-2 haplotypes. This antigen is not expressed in normal tissues of C3HfeB/HeN mice but is expressed in C3H/HeN mice, the strain from which the C3HfeB/HeN mice were originally derived. The present study indicates that spleen cells from C3HfeB/HeN and C3H/HeN mice respond reciprocally in the mixed lymphocyte reaction. Cytotoxic T lymphocytes specific for the tumor-associated alloantigen can be readily generated in mixed lymphocyte reactions in which spleen cells from C3HfeB/HeN mice are reacted with x-irradiated spleen cells from C3H/HeN or A strain mice. These cells are effective in suppressing the growth of the C3HfeB/HeN-derived lung tumor 85 in x-irradiated syngeneic recipients.