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Human B Cell Differentiation

II. Suppression by T Cells of T-Dependent and T-Independent Plasma Cell Maturation¹

From the Laboratoire d'Immunologie, INSERM U 80, Hôpital E. Herriot, 69374 Lyon Cedex 2, France

Abstract

In vitro human plasma cell generation induced by both T-dependent (PWM) and T-independent (NWSM) mitogens was found to be suppressed by peripheral blood lymphocytes preincubated with human aggregated IgG. T cells, but not B lymphocytes, were able to mediate the suppressive activity; since aggregated (Fab)'₂ fragments were found unable to generate suppressor cells, it was concluded that the suppressor cell was a T lymphocyte bearing Fc receptors. These cells appeared to be largely radiosensitive. In most cases the proliferative responses remained unchanged. Since NWSM-induced activation is not dependent on the presence of T cells, these results show that, at least in this case, T cells exert their suppressor function directly on B lymphocytes. Whether PWM-induced B cell differentiation is suppressed by the same mechanism or/and by inactivation of T helper lymphocytes remains under investigation.

Footnotes

¹ This work was supported by INSERM Grant ATP 76-59 and DGRST (Contract 77-7-1381).

² Chargé de Recherche INSERM.