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Immunoregulatory Circuits among T Cell Sets: Effect of Mode of Immunization on Determining Which Lyl T Cell Sets Will be Activated¹

From the Laboratory of Cellular Immunology, The Howard Hughes Medical Institute, RKG, Director; The Yale University Medical Center, New Haven, Connecticut 06510; The Memorial Sloan-Kettering Cancer Center, New York, New York 10021; and The Harvard Medical School, Farber Cancer Institute, Boston, Massachusetts 12115

Abstract

Lyl T cells are able to induce B cells to make antibody and also to induce a resting Ly123 T cell set to exert potent feedback suppression. Which of these two pathways Lyl T cells take can be influenced by the mode of immunization. In particular, in vitro immunized Lyl T cells are more likely to induce suppression than are Lyl T cells immunized in vivo even when both populations deliver the same amount of help to purified B cells. The feedback suppression induced by the Lyl T cells immunized in vitro can be distinguished from suppression mediated by Ly2⁺ T cells; in the former case suppression is preceded by a precocious antibody response, whereas suppression mediated by Ly2⁺ T cells is apparent throughout the entire period of observation.

Footnotes

¹ This work was supported in part by United States Public Health Service Grants AI 13600, AI 12184, AI 10497, CA 08593, and CA 22131.

² Scholar of the Leukemia Society of America.