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The Journal of Immunology, 1979, 122: 1601-1603.
Copyright © 1979 by The American Association of Immunologists, Inc.
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Interferon-Induced Enhancement of IgE-Mediated Histamine Release from Human Basophils Requires RNA Synthesis

Mercedes Hernandez-Asensio, John J. Hooks, Shiroh Ida, Ruben P. Siraganian and Abner Louis Notkins

From the Laboratory of Oral Medicine and the Laboratory of Microbiology & Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205

Abstract

Incubation of human leukocytes with certain viruses results in the enhancement of IgE-mediated release of histamine. This enhancement is produced by interferon. The present experiments show that an induction period of 6 to 9 hr and new RNA synthesis are required for interferon to enhance histamine release. This points to the possibility that interferon may exert its antiviral and histamine-release enhancing activities by acting through a common pathway.






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