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Hybrid Resistance to BALB/c Plasmacytomas

II. Radiation Sensitivity and Silica Insensitivity of Resistance to MPC-11¹

From the Department of Pathology, New York University Medical Center, New York 10016

Abstract

Resistance to the BALB/c plasmacytoma MPC-11 by F₁ hybrids between BALB/c and four C57BL/10 congenic resistant strains was abrogated or reduced by 450 rads total body irradiation but was unaffected by intravenous injection of 3 to 4 mg of silica. These results are consistent with the idea that hybrid resistance to MPC-11 depends on an active immune response and is different from Hh-1 controlled hybrid resistance.

Footnotes

¹ This work was supported by American Cancer Society Grant VC-253 and, in part, by United States Public Health Service, National Institutes of Health Grants CA 20045 and CA 16247.

² Recipient of Research Career Development Award AI 70653 from the National Institute of Allergy and Infectious Diseases.