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The Activation of Guinea Pig T Lymphocytes by Anti-₂-Microglobulin Serum

From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and the Department of Physiological Chemistry, Faculty of Medicine, University of Lund, Lund, Sweden

Abstract

In order to study further the role of ₂-m in the regulation of the immune response, we have examined the effects of a goat anti-guinea pig ₂-m serum on a number of T lymphocyte functions in vitro. Anti-₂-m serum produced a marked inhibition of the response of peritoneal exudate T cells to antigen and mitogen stimulation. Surprisingly, a marked activation of lymph node T lymphocyte proliferation was observed in the absence of antigen or mitogen stimulation. This stimulatory effect of anti-₂-m serum was shown to be specific for ₂-m and required the presence of macrophages. The T cell proliferative response induced by anti-₂-m could not be blocked by antisera to the antigens of the guinea pig MHC. These studies suggest that ₂-m may play some critical role in the immune response at the level of T cell activation.

Footnotes

¹ Deceased June 1978.

² To whom correspondence should be addressed.