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The Journal of Immunology, 1979, 122: 1209-1213.
Copyright © 1979 by The American Association of Immunologists, Inc.
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Studies on the Terminal Stages of Immune Hemolysis

IV. Effect of Metal Salts

Michael D. P. Boyle, John J. Langone and Tibor Borsos

From the Laboratory of Immunobiology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

The inhibitory effects of metal salts on the formation and transformation of E* to ghosts was studied. Ferrous and ferric salts inhibited the binding of C9 to EAC1–8 cells but had no other inhibitory role in the reaction. Uranyl, copper, and zinc salts inhibited the transformation of the EAC1–9inserted intermediate to E ghosts. This inhibition occurred at a stage prior to detectable damage as measured by 86Rb or hemoglobin release and at a step prior to that inhibitable by high molarity EDTA. Consequently a further step in the reaction sequence of E* to ghosts was identified. The reaction sequence leading from EAC1–9 to ghosts can be summarized as follows:
Figure 1






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