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IgA Anti-Dextran B1355 Responses¹

From the Department of Medicine, University of California, San Diego, La Jolla, California 92093

Abstract

Injection of mice bearing the Ig-1^a allotype with dextran Bl355 results in an IgM antibody response that is generally regarded as thymus independent. Moreover, the antibody is directed to [1,3] determinants on dextran Bl355 and shares cross-reacting idiotypic determinants with a ₁ IgA (J558) myeloma protein as well as a ₁ IgM (MOPC 104E) myeloma protein. In this study, we show that BALB/c (Ig-1^a) mice injected with dextran Bl355 produced highly significant IgA anti-dextran responses with specificity directed to the [1,3] epitope. Kinetics of the IgA anti-dextran response in BALB/c mice paralleled kinetics of the IgM response. However, the magnitude of the IgA response was markedly T cell dependent and age dependent.

Footnotes

¹ This work was supported by United States Public Health Service Grant AM-70283 and a grant from the National Foundation for Ileitis and Colitis, Inc.

² Dr. Kagnoff is recipient of Research Career Development Award 1KO4AM-00021 from the National Institute for Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland.