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Some Quantitative Aspects of the Passive Sensitization of Human Basophils^1,2,

From the Theoretical Division, University of California Los Alamos Scientific Laboratory, Los Alamos, New Mexico 87545, and The Johns Hopkins University School of Medicine, Division of Clinical Immunology, The Good Samaritan Hospital, Baltimore, Maryland 21239

Abstract

We review the theory for the binding of IgE to Fc receptors on basophil surfaces. We then use the theory to analyze binding experiments of Malveaux et al. and T. Ishizaka on the passive sensitization of basophils from a patient with chronic myelocytic leukemia and 75% basophilia. From their data we determine that the forward rate constant for the binding of human IgE to receptors on these human basophils is (3.0 ± 1.0) x 10⁴ M^-1 sec^-1.

Footnotes

¹ This work was supported by Grant AI 07290 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and was performed under the auspices of the Department of Energy.

² This is Publication No. 331 of the O'Neill Research Laboratories, The Good Samaritan Hospital, Baltimore, Maryland 21239.

³ Present address: Department of Medicine, Howard University Hospital, Washington, D. C. 20060.

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