HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Muchmore, A. V. Articles by Blaese, R. M. Search for Related Content PubMed Articles by Muchmore, A. V. Articles by Blaese, R. M.

Synergistic Cytotoxicity

II. In Vitro Arming of Monocytes and T Cells by a Heat Labile Fraction of Human Plasma

From the Cellular Immunology Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

In a previous paper we demonstrated that freshly obtained human plasma contained a heat labile nonantibody factor that induced human mononuclear cells to become nonspecifically cytotoxic toward xenogeneic but not allogeneic RBC targets. We now present evidence that this factor has a loose affinity for human monocytes and human T cells and can arm them to kill xenogeneic RBC targets. Furthermore, proteolytic enzymes markedly enhance this arming effect. This ability to be armed by a heat labile component found in fresh human plasma and the fact that proteolytic enzymes markedly enhance cytotoxicity clearly dissociate this model of nonspecific cytotoxicity from previously reported NK models.