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Macromolecular Insoluble Cold Globulin (MICG): A Novel Protein from Mouse Lymphocytes

III. Relationship to the Mixed Lymphocyte Reaction and Effect of anti-MICG Antiserum in Vivo

From the Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Abstract

In the present communication we have examined the relationship between the synthesis of macromolecular insoluble cold globulin (MICG) and the mixed lymphocyte reaction (MLR). In addition, we have studied in vivo the effect of antiserum to MICG on the antibody response to sheep red blood cells. The experiments indicate that MICG synthesis compared to either IgM or total protein is selectively stimulated in responder T cells exposed to allogeneic stimulator cells in the MLR. Furthermore, cytotoxicity studies utilizing anti-MICG antiserum demonstrated that T cells bearing MICG on their surface are an essential component of the responder cell population in the MLR.

In vivo administration of antiserum to MICG significantly suppressed both the primary and secondary antibody response to sheep red blood cells. A possible mechanism for this suppression is discussed.

Footnotes

¹ Address all correspondence to: Stephen P. Hauptman, Cardeza Foundation, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, Pennsylvania, 19107.