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Immunoregulation of Heymann's Nephritis

I. Induction of Suppressor Cells¹

From the Division of Immunology, Department of Medicine and Department of Microbiology, University of Cincinnati Medical School, Cincinnati, Ohio 45267

Abstract

Pretreatment of Lewis rats with a series of injections of a renal tubular antigen (RTA) in IFA prevented induction of Heymann's nephritis (HN) when the rats were challenged with RTA in FCA. This absence of disease was confirmed by immunofluorescent staining for rat IgG and histologic examination of the kidneys as well as by lack of development of significant proteinuria. Passive transfer of spleen and lymph node cells from rats receiving such pretreatment into syngeneic recipients prevented induction of HN when these recipients were challenged with RTA in FCA. Passive transfer of serum obtained from pretreated rats was without effect. These results suggest that one of the mechanisms involved in preventing HN by this pretreatment regimen was the induction of suppressor cells. The results of spleen cell transformation indicated that the suppressor cells were specific for RTA as the immune response to a second antigen, PPD, was unaffected. When rats already had active early HN, the disease course was unaffected by transfer of suppressor cells.

Footnotes

¹ This work was supported in part by an Arthritis Foundation Clinical Research Center grant, the Southwestern Ohio Chapter of The Arthritis Foundation, and the Geier Fund.

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