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Immune-Type Interferon-Induced Transfer of Viral Resistance¹

From the Department of Microbiology, University of Texas Medical Branch, Galveston, Texas 77550

Abstract

Mouse immune-type interferon (type II), a lymphokine, caused the transfer of viral resistance from mouse L cells to human WISH cells. The interferon was incapable of protecting WISH cells in the absence of L cells. The transfer of viral resistance occurred with interferon preparations of various specific activities, and was in proportion to the interferon concentration in te preparations. The transferred resistance had the characteristics of an interferon-induced antiviral state in that it was blocked by actinomycin D, effective against different types of viruses, and resulted from an action on the cell rather than on the virus. Mouse immune-type interferon was more efficient than virus-type (type I) at eliciting the transfer of protection. The transfer phenomenon may represent a mechanism for amplification of the interferon system as a host defense against viral infection. Further, it serves as a model for studying the mechanism of lymphokine-induced transfer of information between cells.

Footnotes

¹ This study was supported in part by American Cancer Society Grant IM-148 to H.M.J. and United States Army Medical Research and Development Command Contract. DAMD 17-78-C-8048 to J.E.B.

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