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Inhibition of Human Killer Cells by Autologous Lymphocytes¹

Division of Tumor Immunology, Fred Hutchinson Cancer Research Center, and Department of Microbiology and Immunology, University of Washington, Seattle, Washington 98104

Abstract

Human antibody-dependent cellular cytotoxicity (ADCC) mediated by K cells is shown in this study to be inhibited by autologous lymphocytes. Inhibitor activity resides in a population of lymphocytes lacking Fc receptors, i.e., depletion of Fc receptor-bearing lymphocytes on immobolized enriches for inhibition. A T cell-enriched population does not inhibit. The effect is not steric inhibition since addition of large numbers of sheep or chicken erythrocytes does not decrease ADCC. Spontaneous cytotoxicity mediated by NK cells in the absence of added antibody is not inhibited by the FcR-depleted population, indicating that K and NK cells differ from each other in this respect.

Footnotes

¹ This study was supported by Grant CA-18647 from the National Cancer Institute, Department of Health, Education and Welfare.