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Suppression of Antibody-Sensitized Tumor Cells by Macrophages: Insufficient Supply or Activation of Macrophages within Large Tumors¹

Department of Laboratory Medicine and Microbiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Abstract

Systemic administration of antibody against the C3H lymphosarcoma 6C3HED caused complete suppression of the growth of 10⁵ tumor cells. When the size of the tumor inoculum was increased to 10⁶ tumor cells, excess antibody was unable to cause complete suppression unless exogenous macrophages were added to the tumor inocula. The decreased effectiveness of antibody was shown to be caused by a local deficiency in the supply or activation of macrophages within the large tumor grafts and not by a systemic deficiency.

Footnotes

¹ This work was supported by National Institutes of Health Grant 1 R01 CA-14113, a grant from the Leukemia Research Foundation, Inc., and R. S. was supported by the National Institutes of Health Medical Scientist Training Program, 5 T32-GM07309. Part of this work was presented at the Meetings of the Federation of American Societies for Experimental Biology held in Chicago, Illinois, April 4–8, 1977.