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High Responder Rabbits to SRBC, a Familial Incidence¹

From the Department of Biology, Syracuse University, Syracuse, New York 13210

Abstract

Three litters of rabbits from our closed colony when immunized with multiple i.v. injections of SRBC gave unusually high titers compared to other rabbits immunized in a similar fashion. Data suggest that this response is a familial occurrence. The antisera from the high responding rabbits also exhibited other unique properties in addition to the high agglutinin titers. The early bleedings had significantly higher amounts of IgG anti-SRBC antibodies but similar amounts of IgM anti-SRBC antibodies relative to normal rabbits immunized with SRBC. The IgG antibodies from the high responders were low avidity antibodies and may exhibit limited heterogeneity.

Footnotes

¹ This work was supported in part by Grant CA19064-02 from the Cancer Institute, National Institutes of Health, and the Senate Research Fund, Syracuse University.

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