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Comparisons of Myeloma Proteins from NZB and BALB/c Mice: Structural and Functional Differences of Heavy Chains¹

From the Division of Biology, California Institute of Technology, Pasadena, California 91125, and the Institute for Cancer Research, Philadelphia, Pennsylvania 19111

Abstract

The N-terminal sequences from heavy variable regions of 47 myeloma proteins of the NZB mouse have been analyzed. Sixteen of these V_H regions have unblocked amino groups and have been analyzed over their N-terminal 20 residues by automatic sequence analysis. These sequence data along with the antigen-binding profiles and immunoglobulin class distribution are compared with comparable data from BALB/c myeloma proteins. These comparisons suggest that the NZB and BALB/c populations of myeloma proteins are distinct from one another. The genetic implications of this conclusion are discussed.

Footnotes

¹ This work was supported by National Institutes of Health Grant AI-10781 and National Science Foundation Grant PCM 76-81542.

² Present address: Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305.

³ Present address: Department of Mathematics, California State Polytechnic University, San Luis Obispo, California 93407.