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From the Immunology Unit, Department of Biology, University of Konstanz, 7750 Konstanz, W. Germany, and the Division of Immunology, Duke Medical Center, Durham, North Carolina 27710
Abstract
Nonspecific T cell-replacing factors prepared as supernatants from mixed lymphocyte cultures or concanavalin A-stimulated spleen cells are active in vivo if injected into nude mice at least 3 days before antigen. The supernatants appear to act by enhancing the weak IgM responses that occur in untreated nudes. Secondary responses and IgG antibody were not found.
Footnotes
1 Present address: German Cancer Research Center, Institute for Immunology and Genetics, 69 Heidelberg 1, W. Germany.
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