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The Journal of Immunology, 1979, 122: 350-354.
Copyright © 1979 by The American Association of Immunologists, Inc.

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In Vivo Activity of a Nonspecific T Cell-Replacing Factor

Berenice Kindred1, Rita Bösing-Schneider and Ronald B. Corley

From the Immunology Unit, Department of Biology, University of Konstanz, 7750 Konstanz, W. Germany, and the Division of Immunology, Duke Medical Center, Durham, North Carolina 27710

Abstract

Nonspecific T cell-replacing factors prepared as supernatants from mixed lymphocyte cultures or concanavalin A-stimulated spleen cells are active in vivo if injected into nude mice at least 3 days before antigen. The supernatants appear to act by enhancing the weak IgM responses that occur in untreated nudes. Secondary responses and IgG antibody were not found.

Footnotes

1 Present address: German Cancer Research Center, Institute for Immunology and Genetics, 69 Heidelberg 1, W. Germany.







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