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Presence of Alpha-1-Antitrypsin on Mitogen-Stimulated Human Lymphocytes¹

From the Departments of Medicine, Pharmacology and Experimental Therapeutics, and Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Abstract

Human lymphocytes that have undergone concanavalin A-induced blastogenetic transformation demonstrate surface alpha-1-antitrypsin by immunofluorescence when examined after 72 hr of culture, whereas unstimulated cells do not. These results may indicate a role for alpha-1-antitrypsin in lymphocyte blastogenesis.

Footnotes

¹ This work was supported by National Institutes of Health Grants GM 23716 and HL 18031 and The Pharmaceutical Manufacturers Association Foundation and the Hospital for Consumptives of Maryland (Eudowood), Baltimore, Maryland. Experiments were performed, in part, in the Alan Bernstein Laboratories of Clinical Pharmacology.

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