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The Effects of Anti-IgD on Serum Immunoglobulins, Antibody Production, and Immunoglobulin-Bearing Cells in Adult Rats¹

From the Department of Microbiology and Immunology, University of Oregon Health Sciences Center, Portland, Oregon and the Delta Regional Primate Research Center, Covington, Louisiana

Abstract

Rabbit anti-rat IgD (-specific) injected subcutaneously into adult rats resulted in hypergammaglobulinemia, increased serum immunoglobulins, increased antibody production, and alterations in the percentages of PBL expressing IgD and IgM. Serum IgM, IgG2a and IgG2c concentrations were increased 100%, 125%, and 200%, respectively, over controls, whereas IgA levels were not altered. Increases in the serum immunoglobulins were predominately due to an increase in antibodies to the rabbit serum components. A depletion of IgD-IgM bearing lymphocytes in the peripheral blood was observed after 24 hr of injection. Percentages of IgD-IgM bearing lymphocytes returned to normal by day 4 and were significantly increased (2-fold) by day 8. The in vivo effects of anti- in rats were similar to those reported in the monkey. Possible modes of action of the anti- and the significance of these results in relation to the biologic function of membrane IgD are discussed.

Footnotes

¹ This work was supported by grants from the N. L. Tartar Foundation, the Oregon Cancer Society, the John A. Hartford Foundation and the Veterans Administration.

² Please address reprint requests to G. A. Leslie, Department of Microbiology and Immunology, UOHSC, 3181 S. W. Sam Jackson Park Road, Portland, Oregon 97201.