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Inosiplex, A Stimulating Agent for Normal Human T Cells and Human Leukocytes¹

From the Departments of Immunology and Rheumatology, Saint-Pierre University Hospital, Free University of Brussels, 1000 Brussels, Belgium

Abstract

The influence of inosiplex upon various in vitro leucocyte assays was studied in normal individuals. It was found that the drug increases the response of bidirectional and unidirectional mixed lymphocyte cultures at concentrations of 200, 300, and 500 µg/ml. It also significantly increases the percentage of active T rosettes (concentration range: 50 to 500 µg/ml) and the percentage of autologous red cell T rosettes (concentration: 100 µg/ml). In contrast, inosiplex did not modify the percentage of total T rosettes and EAC rosettes. Inosiplex increases the number of nonadherent leucocytes in the leucocyte adherence inhibition test at a concentration range between 100 and 300 µg/ml. Finally, inosiplex also increases the percentage of monocytes phagocytizing yeast at a concentration between 50 and 500 µg/ml. These data indicate that inosiplex enhances the function of normal human T cells, monocytes, and possibly neutrophils. Therefore inosiplex appears to have immunostimulant properties.

Footnotes

¹ This work was supported by the Belgian Fonds de la Recherche Scientifique Médicale.

² Address for correspondence: Dr. Joseph Wybran, Service d'Immunologie, Hôpital Saint-Pierre, 322, rue Haute, 1000 Bruxelles, Belgium.