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Serum from Lps Nonresponder C3H/HeJ Mice Does Not Support the Formation of Functional Eac Reagents¹

From the Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021

Abstract

Serum from C3H/HeJ mice in contrast to serum from other mouse strains does not convert EA into EAC. A factor in supportive serum permits nonsupportive C3H/HeJ serum to produce a functional EAC-rosetting reagent. This factor is heat stable. Its concentration in serum parallels the sensitivity of mice to LPS. It is absent or inoperative when sensitivity is reduced on a genetic basis and increased when sensitivity is increased by treatment with BCG.

Footnotes

¹ This work was supported in part by National Cancer Institute Grants CA 08748 and CA 17673.