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Murine Ia Antigens: Identification and Mapping of Ia.23 and Further Definition of the I-E Subregion¹

From the Department of Immunology, Mayo Clinic, Medical School and Research Foundation, Rochester, Minnesota 55901 and The Departments of Genetics and Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110

Abstract

The Ia.23 specificity is a private specificity of the H-2^d haplotype which we have assigned to the I-E subregion. It is found on the same Ia molecule that bears Ia.7, a public specificity previously assigned to the I-C subregion of haplotypes H-2^d, H-2^k, H-2^p and H-2^r. We suggest a reassignment of specificity Ia.7 to the I-E subregion to simplify the interpretation of the data presented in this paper and elsewhere, and to permit an orderly description of that part of the I region to the right of I-J.

Footnotes

¹ This work was supported by United States Public Health Service Grants AI 14764 and CA 20500.

² S.E.C. is a Research Career Development Awardee of the National Cancer Institute, CA 00348.

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