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Pharmacologic Control of the Hormonally Modulated Immune Response

III. Prolongation of Allogeneic Skin Graft Rejection and Prevention of Runt Disease by a Combination of Drugs Acting on Neuroendocrine Functions¹

From the Cell Biology Division, Institute of Anatomy, University of Zürich, Gloriastrasse 19, 8006 Zürich, Switzerland

Abstract

A recently developed pharmacologic means for suppressing acquired immunity by drugs acting on neuroendocrine regulation has been applied to transplantation immune reactions. A number of drugs have been tested singly and in combination for their capacity to suppress the immune response of mice grafted with allogeneic skin. Another model involved newborn F₁ hybrid recipients inoculated with spleen cells from donors of parental strains that had been made specifically "unresponsive" by drug and alloantigen treatment. These procedures led to the identification of a combination of four drugs that induced a remarkable delay in allograft rejection and a prolonged unresponsiveness to alloantigens. This combination of drugs also abrogated the graft-vs-host-runting syndrome in newborn hybrid recipients.

Footnotes

¹ This work was supported in part by the Institute Choay, Paris, France.