HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Pasternack, G. R. Articles by Shin, H. S. Search for Related Content PubMed Articles by Pasternack, G. R. Articles by Shin, H. S.

Tumor Cell Cytostasis by Macrophages and Antibody in Vitro¹

II. Isolation and Characterization of Suppressed Cells

From the Department of Microbiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Abstract

Tumor cells in a cytostatic state caused by macrophages and antibody were isolated. Such suppressed cells excluded vital dye, incorporated uridine and leucine, and metabolized glucose. They did not, however, incorporate thymidine, nor did they resume cell division in culture. During prolonged culture, these cells eventually died. In this system, cytostasis was an all-or-nothing phenomenon at the level of the individual cell. Once in the cytostatic state tumor cells did not resume proliferation.

Footnotes

¹ This work was supported by Public Health Service Research Grant 1 R01 CA-14113 and a grant from the Leukemia Research Foundation, Inc. Part of this work was presented at the Meetings of the Federation of American Societies for Experimental Biology held in Chicago, Illinois, April 1 to 8, 1977.