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Antibody-Induced Suppression of the Fifth Component of Complement in Mice^1,2,

Department of Medicine, Michael Reese Hospital and Medical Center, and the Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60616

Abstract

We have shown that administration of anti-C5 antibody to newborn mice heterozygous for C5 deficiency can suppress C5 levels for prolonged periods. This is analogous to antibody-induced immunoglobulin allotype and idiotype suppression. Only certain sources of anti-C5 are effective in suppression. Of the three antisera extensively tested in (SWR x RIII)F₁ hybrids, A/He anti-RIII was the most effective, SWR anti-RIII was less effective, and SWR anti-DBA/1 was ineffective. Only certain strain combinations of F₁ hybrids are susceptible to C5 suppression. C5 suppression was seen with (SWR x RIII)F₁ hybrids but not (SWR x DBA/1)F₁ hybrids. Kinetics of C5 suppression suggest a requirement for an active, ongoing process in the maintenance of low C5 levels.

Footnotes

¹ This work was supported by the Medical Research Institute Council, Michael Reese Hospital and Medical Center, Research Grant AI 12792 from the National Institutes of Health, and a research grant from the Leukemia Research Foundation, Inc., Chicago, Illinois.

² Presented in part at the annual meeting of the Federated Societies for Experimental Biology, April 1977 (Fed. Proc. 36:1250).