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A Hitherto Undescribed Anomaly in Blood Groups

From the Medical Department and Pathological Laboratory, Mount Sinai Hospital, New York

Abstract

In a case of splenomegaly, hemolysis with a subsequent acute failure of liver function followed a transfusion. The donor's blood contained an abnormal agglutinin active not only against the cells of the patient (who like him belonged to Group III) but also against cells of Groups I, II, and III. It behaved practically like the blood of a foreign species of animal.

It can be inferred that:

1. Donors whose serum agglutinates the cells of the patient (for example "universal" donors, Group I, for patients of Group II, III, or IV) are not necessarily safe.

2. Hemolysis if it occurs is particularly dangerous in diseases of the liver and spleen.

3. It is not enough in transfusion to depend on identity of groups. "Cross tests" of donor's and patient's serum on each other's cells must invariably be done. By this means the danger of hemolysis due to "sub-groups" or rare anomalies can be completely avoided.

This article has been cited by other articles:

				J. BORDLEY III REACTIONS FOLLOWING TRANSFUSION OF BLOOD, WITH URINARY SUPPRESSION AND UREMIA Arch Intern Med, February 1, 1931; 47(2): 288 - 315. [Abstract] [PDF]