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Development of Cellular Anti-Tumor Immunity in Chickens Bearing Tumors Induced by Rous Sarcoma Virus¹

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, and Départment de Microbiologie et d'Immunologie, Université de Montréal, Montréal, Québec, Canada

Abstract

The technique of peripheral lymphocyte stimulation in response to antigen was used to demonstrate the existence of cell-mediated anti-tumor immunity in chickens bearing tumors induced by avian sarcoma viruses. The expression of this anti-tumor response against virus-containing transformed cell culture supernatant fluids and cell extracts varied among animals in terms of time after inoculation with the oncogenic agent. Animals whose tumors had completely regressed rapidly lost the ability to mount such continuing immunity. In addition, we found evidence that some normal animals express endogenous levels of natural immunity against neoplasms induced by these viruses and/or against the viruses themselves.

Footnotes

¹ This work was supported by grants from the National Cancer Institute of Canada and the Conseil de la Recherche en Sante du Québec.