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Complete Sharing of Light Chain Spectrotypes by Murine IgM and IgG Anti-Streptococcal Antibodies¹

Department of Microbiology and Immunology and the Department of Pathology, Washington University School of Medicine, Division of Biology and Biomedical Sciences, St. Louis, Missouri 63110

Abstract

In order to examine the diversity of antibody light chains, we have developed an analytic isoelectric focusing procedure which permits the routine analysis of L chains from antibodies raised in individual mice. We have used this technique to demonstrate that the light chains of IgM and IgG anti-group A streptococcal antibodies raised in SWR mice are probably shared. Interestingly, numerous light chain spectrotypes are shared between individual mice whose 7S antibody focusing patterns differ.

Footnotes

¹ This work was supported by United States Public Health Service Grant A1-11635, National Science Foundation Grant PCM76-09719, and by the Brown and Williamson Tobacco Corporation; Larus and Brother Company, Inc.; Liggett & Myers, Incorporated; Lorillard, a Division of Loews Theaters, Inc.: Phillip Morris, Inc.; R. J. Reynolds Tobacco Company; United States Tobacco Company; and Tobacco Associates, Inc.

² Supported by the Medical Scientist Training Program Grant GM-02016.