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Cellular Components of Allograft Rejection: Identity, Specificity, and Cytotoxic Function of Cells Infiltrating Acutely Rejecting Allografts¹

Immunology Laboratory, Renal Division, Department of Medicine and Surgical Research Laboratory, Department of Surgery, Peter Bent Brigham Hospital, a Division of Affiliated Hospitals Center, Inc., Harvard Medical School, Boston, Massachusetts 02115

Abstract

Functioning Mononuclear cells have been harvested from heterotopic rat cardiac allografts during maximal transplant cellular infiltration. T cells, identified by a T cell-specific absorbed rabbit anti-rat brain serum, constituted two-thirds of the total cells recovered. Approximately 20% of the infiltrating cells bear and synthesize surface immunoglobulin. Macrophages, identified by latex ingestion and morphologic and cytochemical techniques, comprise 9% of the graft infiltrate. Donor-specific cytotoxic T lymphocytes are concentrated within the graft. A separate population of Fc receptor-positive recovered cells mediate antibody-dependent LMC (Ab-LMC). Neither effector cell was adherent or phagocytic. These studies have conclusively established that cytotoxic T lymphocytes accumulate within rejecting allografts; however, the enriched presence of cytotoxic T cells within the grafts is not fully dependent upon antigen recognition per se, since Lew animals grafted with both BN and BUF hearts have Lew anti-BN and Lew anti-BUF killer cells in each graft.

Footnotes

¹ This work was supported by National Institutes of Health Grant CA-16937.

² Recipient, National Institutes of Health Research Career Development Award.

³ Investigator, Howard Hughes Medical Institute.

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