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Studies on Antigen-Induced Arthritis in Mice

III. Cell and Serum Transfer Experiments¹

From the Clinical Research Unit and the Experimental Pathology Unit, The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia

Abstract

Antigen-induced arthritis in mice occurs after immunization and subsequent intraarticular challenge with methylated bovine serum albumin (mBSA). In adoptive transfer experiments, susceptible C57BL mice and resistant CBA mice were compared in their capacity to express delayed-type hypersensitivity (DTH) by ear assay, and to express arthritis. The expression of DTH could be transferred incrementally by lymphoid cells in C57BL mice, but not in CBA mice. Both immune lymphoid cells and, to a much lesser extent, serum transferred the capacity to develop arthritis in C57BL mice. The reactivity of transferred cells was abolished by anti-Thy-1 but enhanced by enrichment for T cells with anti-immunoglobulin columns. If this model disease can be equated with human rheumatoid synovitis, the lesions in the human disease would be an expression of a T cell-dependent activity

Footnotes

¹ This work was supported by grants from Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung, Bern, Credit No. 831.179.73 and the National Health and Medical Research Council of Australia.

This is publication 2242 of the Walter and Eliza Hall Institute of Medical Research.

² Present address: Rheumatologische Universitätsklinik, Felix Platter-Spital, Burgfelderstrasse 101, CH-4055 Basel, Switzerland.

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