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Tumor Growth and Antibodies after RSV-Challenge in Normal Chickens and in Chickens Congenitally Infected with Avian Leukosis Virus¹

From the Department of Microbiology, Mayo Clinic and Mayo Medical School, Rochester, Minnesota 55901

Abstract

Normal chickens and chickens congenitally infected with an avian leukosis virus (ALV) of antigenic subgroup A were challenged with strains of Rous sarcoma virus (RSV) of two different antigenic subgroups (B and C) and tumor induction and growth as well as humoral antibody to viral envelope antigen (VEA) and tumor-specific surface antigen (TSSA) were measured. There was no effect of congenital ALV infection on RSV tumor incidence or latent period but the growth rate and size of the tumors were much higher in congenitally infected birds as compared to controls. Whereas most tumors in the RSV-challenged normal birds regressed, tumors in ALV-infected birds grew progressively. There were no striking differences in the number of birds in either group in the incidence of anti-TSSA or anti-VEA antibodies nor did the presence of either type of antibody reflect the tumor status of the host.

Footnotes

¹ This work was supported by Public Health Service Grant CA 15494 from the National Cancer Institute.