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Influence of H-2 Complex on Susceptibility to Infection by Murine Leukemia Virus¹

From the Hematology Service, New England Medical Center Hospital, and the Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111

Abstract

Titers of infectious ecotropic MuLV in mouse spleen were examined after deliberate infection. In congenic mice differing only in H-2 haplotype, a gene (or genes) within the H-2 complex determined either a high virus titer (H-2^k, H-2^d, H-2^a) or a low titer (H-2^b, H-2^q). Susceptibility to high virus titers was inherited as a dominant trait. Kinetic studies revealed similar initial patterns of infection in both groups, with a fall in titer in the "resistant" strain occurring from week 6 through 10 after infection. Anti-VEA antibody titers differed significantly between the groups, but no mechanistic role for antibody in eliminating virus was apparent. Genes outside the H-2 complex were shown to influence MuLV titers after infection as well.

Footnotes

¹ This work was supported by United States Public Health Service Grants CA 10018 and AM 07937, and a Contract from the National Institutes of Health (N0-1-CP-61046).

² Present address: Rush Presbyterian-St. Lukes Hospital, 1753 Congress Parkway, Chicago, Illinois 60612.

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