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Radiosensitivity of T and B Lymphocytes

IV. Effect of Qhole Body Irradiation upon Various Lymphoid Tissues and Numbers of Recirculating Lymphocytes¹

From the Departments of Pathology and Radiology, University of New Mexico, and Department of Microbiology, University of Arizona, Tucson, Arizona

Abstract

Groups of 10-week-old female CBA/J mice were exposed in whole body fashion to 0, 5, 50, and 500 rads and sacrificed in serial fashion 1, 3, 5, 7, 9, 15, and 30 days after irradiation for morphologic evaluation of thymus, spleen, lymph node, and Peyer's patch, and assessment of the relative numbers of thymus-derived (T) and bone marrow-derived (B) cells in these tissues. The absolute and relative numbers of recirculating T and B cells mobilizable by thoracic duct cannulation were also determined and compared with similar determinations with respect to peripheral blood lymphocytes.

B cell depletion occurred more quickly and was more pronounced in spleen and lymph node than T cell depletion at all three exposure doses. Depletion of T and B cells was roughly equal in peripheral blood and thoracic duct lymph. When present, regeneration of the T cell component occurred more rapidly than did B cell restoration. The latter often was incomplete at the time of the final sacrifice (day 30). PHA-responsive and Con A-responsive cells also appeared to differ with respect to the kinetics of cell death after whole body irradiation.

Footnotes

¹ This work was supported by Research Grants CA 15593 and CA 13805 awarded by the National Cancer Institute, Department of Health, Education and Welfare, and from the Albuquerque Veterans Administration Research Funds.

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