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The Journal of Immunology, 1977, 118: 1132-1137.
Copyright © 1977 by The American Association of Immunologists, Inc.
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Interactions between Human Lymphocytes and Paramyxovirus-Infected Cells: Adsorption and Cytotoxicity1

Bengt Härfast, Torbjörn Andersson, Vera Stejskal and Peter Perlmann

From the Department of Immunology, The Wenner-Gren Institute, University of Stockholm, and the Department of Infectious Disease, Roslagstull Hospital, Stockholm, Sweden

Abstract

The capacity of human lymphocytes to adhere to paramyxovirus-infected monolayers and their capacity to kill paramyxovirus-infected cells was investigated. A large fraction of human lymphocytes was found to adhere firmly to the paramyxovirus-infected monolayers. Preadsorption of lymphocytes on mumps virus-infected cells impaired their adsorption to a second cell monolayer of the same type. The cytotoxic activity of lymphocytes against mumps virus-infected cells was also reduced after preadsorption on mumps virus- or Newcastle disease virus-infected (NDV) cell monolayers. Exposure of lymphocytes to trypsin did not significantly decrease either adsorption or cytotoxicity. Pretreatment of lymphocytes with neuraminidase (NANase) partly inhibited adsorption whereas cytotoxicity was not decreased. Cell fractionation experiments after rosetting of the lymphocytes with sheep erythrocytes (E) indicated that T cells were equally or better adsorbed than "non-T" cells. Taken together with previous experiments which showed that the majority of T lymphocytes are not cytotoxic against mumps virus-infected cells these results suggest that adherence of lymphocytes to infected cells and cytotoxicity may be unrelated phenomena.

Footnotes

1 This work was supported by Swedish Medical Research Council Grant B77-16X-4973-01.






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