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Inhibition of Antibody-Dependent Cellular Cytotoxicity by Protein A from Staphylococcus Aureus¹

From the Immunobiology Group, Department of Microbiology and Immunology, and the Department of Pediatrics, University of California at Los Angeles School of Medicine, Los Angeles, California 90024

Abstract

Protein A, a cell wall constituent of several strains of Staphylococcus aureus, binds strongly to the Fc portion of immunoglobulins. This investigation demonstrated that such binding can inhibit antibody-dependent cellular cytotoxicity (ADCC). The degree to which ADCC was inhibited depended upon the relative concentrations of protein A and anti-target cell antiserum. Protein A also inhibited the formation of rosettes between antibody-coated sheep red blood cells and lymphoid cells with Fc receptors. We, therefore, conclude that protein A inhibits ADCC by preventing the binding of antibody-coated target cells to Fc receptors on cytotoxic effector cells.

Footnotes

¹ This work was supported by United States Public Health Service Grant CA 12800.

² P. M. Z. was supported by Public Health Service Grant T01A100431; R. C. S. is the recipient of Research Career Development Award 5 K04 CA00069 from the National Cancer Institute.

³ Address correspondence to Dr. Seeger at the Department of Pediatrics, UCLA School of Medicine, Los Angeles, California 90024.

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