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Effects of Lymphocytes from Marek's Disease-Infected Chickens on Mitogen Responses of Syngeneic Normal Chicken Spleen Cells¹

Department of Pathology, New York Medical College, Valhalla, New York 10595

Abstract

PHA responses have been measured in lymphoid cell cultures prepared by mixing normal chicken spleen cells with spleen or thymus cells from syngeneic chickens infected with the oncogenic herpesvirus MDV. Results of these studies may be summarized as follows: 1) spleen cells from MDV-infected chickens with visceral lymphomas inhibit the PHA response of normal spleen cells possibly by release of soluble inhibitory factors in response to the mitogen; 2) lymphoid cells from asymptomatic MDV-infected chickens, although hyporeactive themselves to PHA, can have a stimulatory effect on PHA responses of normal spleen cells in mixed cultures; 3) spleen cells from MDV-infected chickens, effectively protected from viral oncogenesis by HVT vaccination, show normal reactivity to PHA in separate cultures and may react in mixed cultures like normal lymphocytes, with neither a pronounced stimulatory nor inhibitory effect on the PHA response of normal spleen cells.

Footnotes

¹ This work was supported in part by Grant CA 18904 from the National Cancer Institute, United States Public Health Service.

² Recipient of Research Development Award K04 CA70812 from the National Cancer Institute.

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