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Lipopolysaccharide-Induced Suppression of the Primary Immune Response to a Thymus-Dependent Antigen¹

From the Division of Immunobiology, Karolinska Institutet, Wallenberglaboratory, Lilla Frescati, 10405 Stockholm 50, Sweden

Abstract

The immune response to a thymus-dependent antigen was depressed in vivo and in vitro in spleen cells from mice injected with LPS i.p. a few days before challenge with the antigen. Spleen cells from LPS-injected mice could, however, respond with increased DNA synthesis after activation with polyclonal B and T cell activators in vitro. The LPS-activated spleen cells could actively suppress normal cells in their response to the antigen sheep red blood cells. The suppressor cells contained in the LPS-activated spleens were most likely B lymphocytes, and the possible mechanism for their inhibitory function is discussed.

Footnotes

¹ This work was supported by the Swedish Cancer Society.

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