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The Journal of Immunology, 1977, 118: 1086-1089.
Copyright © 1977 by The American Association of Immunologists, Inc.
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Isolation of Mouse C-Reactive Protein from Liver and Serum

Barbara Bodmer1 and Russell Siboo

From the Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada

Abstract

Purified proteins have been isolated from the sera and livers of mice. These proteins are antigenically identical but share antigenic determinants in common with human C-reactive protein and do not share antigenic determinants in common with mouse or human immunoglobulins. The proteins interact with C-polysaccharide, are precipitated by calcium ions, migrate electrophoretically with gamma mobilities, and have isoelectric points of 4.8 and 5.62. Since these properties are characteristic of C-reactive protein of man, monkey, rabbit and dog, the pure proteins isolated from mice are designated mouse C-reactive protein.

Footnotes

1 B. B. is the recipient of a Medical Research Council Studentship.




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