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Structure and Biologic Functions of Human IgD

XI. Identification and Ontogeny of a Rat Lymphocyte Immunoglobulin Having Antigenic Cross-Reactivity with Human IgD¹

From the Department of Microbiology and Immunology, University of Oregon Health Sciences Center, Portland, Oregon 97201

Abstract

Chicken anti-human IgD antiserum (anti-) has demonstrated an antigenically cross-reactive homologue on rat lymphocytes. IgD and IgM are the only cell surface immunoglobulins detectable by the lactoperoxidase radiolabeling technique employed. The results indicate that, although rat surface IgD is antigenically distinct from rat IgM, the respective H chains co-electrophorese in 10% polyacrylamide-SDS gels. Rat -chain has an apparent m.w. of 73,000 daltons and exhibits a minor 65,000 dalton component which probably represents a partially degraded -chain. The ontogenic emergence of rat IgD occurs 3.5 weeks after birth whereas IgM, in contrast, is apparent by 6 days of age. Thus, as in the human, IgM develops before IgD. IgD receptors are undetectable in the thymus but are present in increasing levels in spleen, blood, lymph nodes, and Peyer's patches.

Footnotes

¹ This work was supported by National Institutes of Health Grant AI 12273 and by a grant from the John A. Hartford Foundation, Inc.

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