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Tolerizing Effect of DNP-Ficoll on IgE Antibody Production¹

From the Department of Pathology, New York University Medical Center, 550 First Avenue, New York, New York 10016

Abstract

A/J and DBA/1 mice were infected with 750 third-stage larvae of Nippostrongylus brasiliensis and immunized with 1 µg dinitrophenylated N. brasiliensis extract (DNP-Nb) with 1 mg Al(OH)₃ to produce high titers of anti-hapten IgG1 and IgE antibody. Partial tolerance to the production of anti-hapten IgG1 and IgE antibody could be induced by DNP-Ficoll from 5 weeks before to 1 week after the DNP-Nb immunization. The tolerized state persisted through the duration of the experiments. However, no tolerizing effect could be demonstrated on secondary anti-hapten IgE antibody production induced by DNP-Nb. Moreover, DNP-Ficoll failed to evoke anti-hapten IgG1 or IgE antibody production.

Footnotes

¹ This work was supported by National Institute of Health Grant AI-03075-17 and National Cancer Institute Grant 5-PO1 CA 16247-02.

² Supported by National Cancer Institute Grant 5-PO1 CA 16247-02, Jikei University School of Medicine, Tokyo, Japan, and recipient of Fellowship from the Cancer Institute Inc., New York, N. Y.

³ Recipient of Fellowship from The Cancer Institute Inc. New York. Present address: Department of Parasitology, School of Medicine, Chiba University, Chiba, Japan.