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The Development of HB_sAg-Positive Hepatitis Despite the Previous Existence of Antibody to HB_sAg

From the Blood Bank Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014 and the Gastroenterology Branch, Internal Medicine Service, National Naval Medical Center, Bethesda, Maryland 20014

Abstract

A dentist developed acute, icteric HB_sAg-positive hepatitis despite the prior existence of anti-HB_s. Evaluation of this antibody showed it to have a restricted specificity reacting with only one subdeterminant (₁) of the hepatitis B surface antigen. The anti-HB_s/₁ coexisted with HB_sAg of subtype ayw in the acute phase hepatitis serum.

Footnotes

¹ Address reprint requests to Paul V. Holland, M.D., 1E33, Bldg. 10A, National Institutes of Health, Bethesda, Maryland 20014.

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