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Maintenance of Hyporesponsiveness to Antigen by a Distinct Subclass of T Lymphocytes¹

From the Department of Medicine, Harvard Medical School, Farber Cancer Center, Boston, Massachusettes 02115 and Memorial Sloan-Kettering Cancer Center, New York, New York 10021

Abstract

Immunization with increasing doses of SRBC, in excess of 10⁸, results in a progressive decline in the anti-SRBC PFC response. This hyporesponsive state is antigen specific and is reflected in a decrease of both T helper and B antibody-forming activity. We asked whether the apparent defect of T helper activity reflected a) an absence of SRBC helper T cell activity, or b) the presence of SRBC-specific suppressor T cells within the hyporesponsive population. Our results indicate that at least a portion of hyporesponsiveness noted after antigen exposure to large doses of antigen can be ascribed to specific suppressor T cell activation.

Fractionation of the suppressive T cell population using Ly antiserum showed that specific suppressive activity was mediated by a subclass of T cells (Ly2⁺), distinct from that committed to express helper function (Ly1).

Footnotes

¹ This work was supported by United States Public Health Service Research Grants AI12184 and AI13600.

² Scholar of the Leukemia Society of America.