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The Journal of Immunology, 1976, 117: 2175-2180.
Copyright © 1976 by The American Association of Immunologists, Inc.
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Activation of Cytotoxic Function in T Lymphocytes1

Diane Heininger, Mary Touton2, Ashim K. Chakravarty and William R. Clark3,4,

From the Molecular Biology Institute and the Department of Biology, University of California, Los Angeles, California 90024

Abstract

The requirements for activation of cytotoxic function in mouse T lymphocytes were investigated. Initial generation of cytotoxicity in normal lymphocytes was equal in magnitude with either Con A or specific alloantigen, and in either case required DNA synthesis. Cytotoxic function in MLC-primed cells could also be regenerated by Con A, the magnitude and target specificity of the cytotoxicity thus generated being indistinguishable from that recalled by specific alloantigen. Cytotoxicity could also be regenerated by third party-stimulating cells; however, the cytotoxicity evoked by third party cells was always specific only for target cells of the original stimulating cell H-2 genotype.

The data presented suggest that there are a number of ways to activate cytotoxicity in effector T cells, and are most consistent with a model for T cell triggering that minimizes a strict informational function of antigen-receptor interactions.

Footnotes

1 This work was supported by research grants from National Institutes of Health (HD-06071), the American Cancer Society (IM-48), and the California Institute for Cancer Research.

2 Supported by Molecular Biology United States Public Health Service Training Grant, GM 1531.

3 Recipient of National Institutes of Health Research Career Development Award AI 00009.

4 To whom further communications should be addressed.






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