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Subpopulations of Human T Cells Identified by Receptors for Immunoglobulins and Mitogen Responsiveness¹

From the Departments of Microbiologia and Medicina del Lavoro, University of Genova, Genova, Italy and the Department of Pediatrics, University of Alabama in Birmingham, University Station, Birmingham, Alabama 35294

Abstract

Human T lymphocytes in peripheral blood have been shown to have receptors for IgG (T) or IgM (Tµ). Cultured T cells do not express receptors for IgM and purified Tµ cells do not have receptors for IgG, thus they appear to be distinct T cell populations. Although the two subpopulations show similar response patterns to concanavalin A, Tµ and T cells exhibit different dose-response curves to phytohemagglutinin. The normal response pattern to phytohemagglutinin requires a mixture of T cell subpopulations suggesting that synergistic interactions may occur.

Footnotes

¹ This work was supported by national Institutes of Health Grant AI-10917, CA 16773, and HD 00413.

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