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The Regulation of the Immune Response to T-Independent Antigens by Prostaglandins and B Cells

From the Roche Institute of Molecular Biology, Nutley, New Jersey 07110

Abstract

The effect of inhibitors of prostaglandin synthesis on the in vitro primary immune response to two T-independent antigens has been investigated. The results, with PVP or DNP-Ficoll, suggest that the prostaglandins play an important role in the regulation of the immune response to these antigens. Furthermore, it appears that B cells may be involved in their own regulation by synthesizing and responding to prostaglandins. Although it has been previously established that T cells exert a regulatory influence on the response to PVP and DNP-Ficoll, this is the first demonstration of an apparent B cell regulation of B cell function via the production of a specific hormone.

Footnotes

¹ M. Z. is the recipient of a Fullbright-Hays Fellowship.