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Functional Heterogeneity Among the T-Derived Lymphocytes of the Mouse

VI. Memory T Cells Stored in the T2 Subpopulation¹

From the Department of Microbiology, Division of Immunology, and The University of Rochester Cancer Center, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642

Abstract

Memory T cells were demonstrated in mice which were the precursors for cells causing sheep red blood cell-(SRBC) specific helper activity in the in vitro response of spleen cells to trinitrophenyl (TNP)-SRBC. These memory cells were distinguished from the effectors of helper activity generated during the primary response and were shown to belong to the T2 subpopulation of peripheral T cells on the basis of 1) their rapid response to a challenge with SRBC, 2) their long lifetime, and 3) their sensitivity to small in vivo doses of anti-thymocyte serum.

Footnotes

¹ This work was supported by United States Public Health Service Research Grants AI-11558 and CA-11988 from the National Institute of Health and the American Cancer Society Research Grant No. IM-49.

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